Reviews

The most rigorous oral microbiome test available DTC — clinical-grade sequencing with actionable output.

The widest DTC panel we've scored, with clinician review and a second draw built into $365/yr. Galleri is extra.

A legitimate attempt at capturing cortisol rhythm — but single-day data has limits. Best for baseline, not ongoing tracking.

A detailed food and supplement plan on a mid-size panel. No clinician review, and $489 in the first year.

Clinical-grade metabolomics — the depth is extraordinary but you need a practitioner to interpret it meaningfully.

Interesting concept, limited validation. Early-stage science — worth watching, not betting on yet.

The most credible DTC NAD test — legitimate assay, useful if you're actively supplementing and want to know if it's working.

Function-level breadth at $349/yr with a 24/7 care team. Watch the supplement upsells.

The cheapest clinician-reviewed panel in our comparison at $199/yr, and the only one tied to wearable data. No membership required since August 2026.

A useful no-Rx starting point for women's hormones — covers reproductive, thyroid, and adrenal health in one kit, but breadth is limited.

The most technically advanced DTC gut test — RNA methodology is differentiated. Food recommendations are useful; independent clinical validation is still catching up.

The only DTC vaginal health test using true metagenomics. Catches organisms every other test misses, and the clinician review + Rx pathway makes it the most complete vaginal health platform available without a specialist referral.

The most frictionless gut data source that exists. Not a diagnostic — but as a passive pattern tracker for GLP-1 users, IBS management, and hydration, it fills a gap nothing else does.

The most evidence-backed at-home semen analysis on the market. FDA-cleared, Cleveland Clinic validated, and useful as a first screen for any man starting a fertility workup — without a lab visit.

One to watch. Stanford-backed platform with 17 years of R&D and 12+ validated analytes. If the human feasibility data holds, this could become one of the most important platforms in continuous health monitoring.

Best-in-class hormone methodology for DTC testing. LC/MS and equilibrium ultrafiltration aren't marketing claims — they're the methods clinicians use when precision actually matters.

The cheapest legitimate blood testing available. Built for self-quantifiers who know what they want and don't need anyone to explain the results.